Alexander Tolios

Alexander Tolios
MD, MD, BA, MA, MSc, MLS

Medical University of Vienna
Department of Transfusion Medicine and Cell Therapy (4i) Waehringer Guertel 18-20
A-1090 Vienna, Austria
+43 140400 -53370 or -53080
alexander.tolios@meduniwien.ac.at https://orcid.org/0000-0001-9163-7127

Clinical Position
current
Physician scientist/Specialist in the field of transfusion and laboratory medicine at the Department of Transfusion Medicine and Cell Therapy (4i), Medical University of Vienna, Vienna, Austria
Head of the platelet immunology and platelet function laboratory
Head of the transfusion medicine clinical routine laboratory
Deputy head of histocompatibilityand immunogenetics laboratory
Deputy head of erythrocyte immunology laboratory

Professional Training
10/2015 - 09/2023 Transfusion Medicine resident and research fellow, Department of
Transfusion Medicine and Cell Therapy, Medical University of Vienna,
Vienna, Austria
07/2020 - 06/2021 Research fellow at the Institute of Vascular Biology and Thrombosis
Research as well as the Institute far Artificial lntelligence and Decision
Support, Medical University of Vienna, Vienna, Austria
04/2017 - 09/2017 Laboratory Medicine resident and research fellow, Institute of Clinical
Chemistry and Laboratory Diagnostics, Heinrich Heine University, Duesseldorf, Germany
07/2013 - 09/2015 Laboratory Medicine resident and research fellow, Institute of Laboratory
Medicine, Ludwig Maximilian University, Munich, Germany
10/2011 - 06/2013 Research fellow and Internal Medicine resident, Department of Physiology
and Department of Internal Medicine, Eberhard Karls University, Tuebingen,
Germany

Education
09/2016 - 03/2019 MSc (Engineering) in the field of Bioinformatics, University of Applied
Sciences, Vienna, Austria
10/2015 - 07/2021 MLS (Master of Legal Studies), University of Economics, Executive
Academy, Vienna, Austria
04/2011 - 11/2016 MA (Musicolo gy), University of Vienna, Vienna, Austria
10/2011 - 05/2013 MD (Dr. med., Research doctorate), Eberhard Karls University, Ti.ibingen,
Germany
10/2008 - 04/2011 BA (Musicology), University of Vienna, Vienna, Austria
10/2005 - 08/2011 MD (Dr. med. univ., Professional doctorate), Medical University of Vienna,
Vienna, Austria

Research interests
Bioinfarmatics, biostatistics/data science and predictive modeling/machine learning Immunohematology and immunogenetic diagnostics
Methods in molecular biology and genetics and laboratory diagnostic techniques Platelet physiology and biochemistry

Acquired grants

• 26.000 Euro via the Medizinisch-Wissenscha licher Fond des Bilrgermeisters der Bundeshauptstadt Wien (Project number 22090) far the Project Analyse von DNA­ Methylierung zur Gewebe-Zuordnung und Tumordetektion, granted 06/2022
• 3.000 Euro via the Austrian Academy of Science far the Project Detecting Cancer of Unknown Primary by Analysis of Epigenetic Markers, granted 09/2022

Selected peer-reviewed publications (excerpt, for full list see bere)

• Thrombomodulin in patients with mild to moderate bleeding tendency. Mehic D, Tolios A, Hofer S, Ay C, Haslacher H, Downes K, Haimel M, Pabinger I, Gebhart J. Haemophilia. 2021 Nov;27(6): 1028-1036. doi: 10.1111/hae.14433.Epub 2021 Oct 10.
• Systematic Analysis of the Transcriptome Profiles and Co-Expression Networks of Tumour Endothelial Cells Identifies Severa/ Tumour-Associated Modules and Potential Therapeutic Targets in Hepatocellular Carcinoma. Mohr T, Katz S, Paulitschke V, Aizarani N, Tolios A. Cancers (Basel). 2021Apr 7;13(8):1768. doi: 10.3390/cancers13081768.
• Elevated leve/s of tissue factor pathway inhibitor in patients with mild to moderate bleeding tendency. Mehic D, Tolios A, Hofer S, Ay C, Haslacher H, Rejto J, Ouwehand WH, Downes K, Haimel M, Pabinger I, Gebhart J. Blood Adv. 2021 Jan 26;5(2):391-398. doi: 10.1182/bloodadvances.2020003464.
• Joining European Scienti fic Forces to Face Pandemics. Vasconcelos MH, Alcaro S, Arechavala-Gomeza V, Baumbach J, Borges F, Brevini TAL, Rivas JL, Devaux Y, Hozak P, Keinanen-Toivola MM, Lattanzi G, Mohr T, Muravska M, Prusty BK, Quinlan RA, Perez­ Sala D, Scheibenbogen C, Schmidt HHHW, Silveira I, Tieri P, Tolios A, Riganti C. Trends Microbiol. 2021 Feb;29(2):92-97. doi: 10.1016/j.tim.2020.10.008. Epub 2020 Dec 4.
• Computational approaches in cancer multidrug resistance research: Identification of potential biomarkers, drug targets and drug-target interactions. Tolios A, De Las Rivas J, Hovig E, Trouillas P, Scorilas A, Mohr T. Drug Resist Updat. 2020 Jan;48:100662. doi: 10.1016/j.drup.2019.100662. Epub 2019 Oct 18.
• Preanalytical Conditions and DNA Isolation Methods Affect Telomere Length Quanti fication in Whole Blood. Tolios A, Teupser D, Holdt LM. PLoS One. 2015 Dec 4;10(12):e0143889. doi: 10.1371/journal.pone.0143889.ECollection 2015.
• Increased platelet Ca2+ channel Orail expression upon platelet activation and in patients with acute myocardial in farction. Tolios A, Gatidis S, Mtinzer P, Liu G, Towhid ST, Karathanos A, Tavlaki E, Geisler T, Seizer P, May AE, Bigalke B, Borst O, Gawaz M, Lang F. Thromb Haemost. 2013 Aug;110(2):386-9. doi: 10.1160/TH12-09-0701. Epub 2013 May 23.